Head Coach: George Murphy (6-6, 2nd and final year)
Record: 2-2
Results
| Date | Opponent | Score | Podcast |
| Oct. 9 | @ Mount Vernon | W 14-12 | The Panthers open 1920 with a win |
| Oct. 16 | @ Owensville | L 6-33 | Kicked around by the Kickapoos |
| Oct. 30 | Mount Vernon | W 36-6 | Gone With The Win |
| Nov. 6 | @ Boonville | L 13-49 | Panthers crushed by the Giants |
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